Tranexamic Acid (TXA)

Tranexamic Acid

The CRASH-2 2 (Clinical Randomisation of an Anti-fibrinolytic in Significant Haemorrhage 2) study involved the randomisation of over 20,000 patients with, or at risk of significant haemorrhage in 40 countries. The study demonstrated a 32% reduction in death due to haemorrhage, when tranexamic acid is administered within 1 h of injury. The study concluded that tranexamic acid safely reduced the risk of death in bleeding trauma patients, and should be considered for use in practice.

Following the publication of the study, the Trust has been working with Professor Stuart Logan, Director of the Peninsula National Institute of Health Research's Collaboration for Leadership in Applied Health Research and Care to implement the intervention across the South West.

Ambulance service Paramedics and Nurses will commence the administration of tranexamic acid to suitable patients from 00:01 on the 30th November 2011. For further information please contact Adrian South, Deputy Director of Clinical Care at

Local Resources

Published Evidence

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The 27 January 2016 was a normal day like any other for Austin Bamford from Nailsea until he experienced acute abdominal pain before collapsing. At the ambulance station nearby, paramedic Gill Shellard and emergency care assistant Michelle Foster had just returned to station for a well-deserved protected meal break eight hours into their shift, when details of the call came in. They volunteered to attend immediately and soon arrived on scene, at which point the patient was conscious, breathing and alert. The results of an initial assessment showed that he had an irregular heart rhythm and he collapsed in cardiac arrest soon after. He was successfully resuscitated before a further medical team arrived.

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